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What is cortisol and how does it affect your health
Many women experience periods of fatigue, unexplained weight gain or a persistent feeling of stress in their lives, often without knowing the precise cause. The fluctuations in hormones during, for example, the (peri)menopause can intensify these complaints and lead to a search for answers. A key role in this is played by the hormone cortisol, which influences virtually every system in the body. When the balance of this essential hormone is disrupted, the consequences can manifest in both physical and mental symptoms that affect daily functioning. Understanding how cortisol works is therefore crucial for anyone who wants to gain control over these challenges and strives for greater vitality.
Table of contents

What is cortisol and what does this hormone actually do?
It plays a crucial role in numerous bodily processes, including regulating your metabolism, managing inflammation and controlling your blood sugar levels. When your body experiences stress, whether physical or emotional, your adrenal glands respond by producing more cortisol. This reaction is naturally intended to help you cope with challenging situations by giving your energy a boost and increasing your alertness. A healthy balance of this hormone is therefore of great importance for your overall well-being.
Influence on metabolism and immune system
Besides the stress response, cortisol has a profound effect on your metabolism and immune system. It aids in the breakdown of proteins, fats and carbohydrates to provide energy, which is especially important during periods of fasting or high energy demand. This hormone also modulates the activity of your immune system, which can explain why prolonged stress can make you more susceptible to illnesses. The Endocrinology Outpatient Clinic focuses, among other things, on disorders of the hormone-producing organs, such as the adrenal glands that produce cortisol, and plays an important role in diagnosing and treating related problems. Endocrinology Department. It is clear that the role of this hormone extends beyond mere stress regulation; it is a pivot in your hormonal health.
How is this stress hormone made in the adrenal glands?
The production of cortisol is a complex process that takes place primarily in the adrenal glands, two small glands situated on top of your kidneys. This process begins in the brain, more specifically in the hypothalamus, which sends a signal to the pituitary gland. The pituitary gland responds by releasing adrenocorticotropic hormone (ACTH), which travels via the bloodstream to the adrenal glands. Upon arrival at the adrenal glands, ACTH stimulates the outer layer of the adrenals, the adrenal cortex, to produce and release cortisol into the blood. The production of this hormone is essential for various bodily functions, including the regulation of blood pressure, a process that is sometimes monitored via a 24-hour blood pressure monitor.
Circadian regulation
The regulation of cortisol production is closely linked to our circadian rhythm, the internal biological clock that determines our sleep-wake cycle. Normally, cortisol levels are highest in the early morning, which helps you to wake up and start the day with energy. Throughout the day, production gradually decreases to reach its lowest point in the evening, which contributes to a good night's sleep. Disruptions to this rhythm, for example due to irregular sleep times or chronic stress, can upset the natural production cycle of cortisol.
What signs indicate too high a cortisol level?
A raised cortisol level can manifest in various ways, which sometimes makes it difficult to trace the cause directly. Physical signs can range from unexplained weight gain, especially around the abdomen and in the face, to changes in the skin, such as thinning or the appearance of stretch marks. You may also experience muscle weakness and elevated blood pressure. It is crucial to take these symptoms seriously and not to ignore them, as a prolonged raised cortisol level can have an impact on your overall health and well-being.
Mental and emotional impact of high cortisol
You might notice that you are more irritable, become stressed more quickly or suffer more from feelings of anxiety. Sleep problems, such as difficulty falling asleep or staying asleep, are also common, which can further increase daytime fatigue. It is important to realise that these psychological symptoms are not isolated issues, but often form a reflection of the underlying hormonal imbalance. A good night's sleep and stress management are therefore essential for restoring balance in the body, and can help to reduce the mental load.
How do you combine relaxation with a busy lifestyle?
It is essential to make conscious choices for moments of rest, even amidst a hectic schedule. This not only helps to maintain your mental resilience, but also supports your physical health. Think of scheduling short breaks throughout the day, practising mindfulness or finding activities that give you energy and take your mind off things. These small interventions can make a big difference in how you deal with daily stressors and the production of stress hormones in your body.
Importance of cortisol day profiles in saliva
Start by identifying moments when you can disconnect, even if only for ten minutes. This could be a short walk, listening to soothing music, or a few deep breathing exercises. The point is to consciously make time for yourself, which helps you to calm your internal system and regulate the production of stress hormones such as cortisol. By integrating these habits, you build up a buffer against everyday stress, which contributes to a more stable hormonal balance and an overall sense of well-being.
Are there supplements that support hormone balance?
When looking for ways to optimise hormone balance, questions about the role of supplements quickly arise. Although supplements can sometimes be a complement, it is important to emphasise that they are no substitute for a healthy lifestyle, including a balanced diet and sufficient exercise. The effectiveness of supplements in supporting cortisol levels depends on the specific situation and the nature of the imbalance. Too high or too low a cortisol level requires a careful approach, often in consultation with a medical specialist. There is no ‘one-size-fits-all’ solution, and the focus remains on addressing the underlying causes of the hormonal disruption.
Impact on typical menopausal symptoms
Specifically for the (peri)menopause, a period in which many women experience hormonal fluctuations that lead to symptoms such as hot flushes, sleep problems and mood swings, caution is advised regarding claims about supplements. The Endocrinology Department of the LUMC, for example, deals with disorders of hormone-producing organs such as the thyroid and adrenal glands, and offers specialist care in this area. pituitary disorders. This underlines the importance of a thorough medical evaluation for hormonal complaints. Although some herbal extracts or vitamins are sometimes mentioned in relation to hormone balance, it is essential to look at the scientific evidence and individual needs in order to prevent unnecessary use or unwanted interactions.

Why do your cortisol levels rise more often during the menopause?
During the menopause, many women experience an increase in the frequency and intensity of fluctuations in their cortisol levels. This is primarily due to the hormonal changes that take place, particularly the decrease in oestrogen. Oestrogen plays a regulating role in the body's stress response, and when its levels drop, sensitivity to stressors can increase. The body responds to this by releasing cortisol more often and sometimes more violently, even in situations that were previously experienced as less stressful. This heightened reactivity of the stress system can lead to a constant state of readiness, which has a lasting effect on your overall well-being.
Personal relaxation and boundary-setting
The Department of Endocrinology of the LUMC deals with conditions, including the adrenal glands that produce cortisol. Elevated cortisol levels during the menopause can lead to a vicious circle, where the physical and emotional symptoms of the menopause itself act as stressors, which in turn further stimulates cortisol production. Think of hot flushes, sleeping problems and mood swings, all of which have an impact on how you feel and how you deal with stress. It is therefore important to gain insight into these complex interactions and to understand how you can support your body during this phase of life.
In what way can you easily measure cortisol yourself?
Measuring cortisol levels yourself is now possible in several ways, although the reliability and interpretation of the results require careful consideration. You can think of self-tests that measure cortisol levels in saliva, urine or even hair. Saliva tests are often preferred because they reflect the free, active form of cortisol and are easy to take at different times of the day, which provides a better picture of the daily rhythm. However, it is crucial to realise that these home tests provide an indication and do not replace a professional diagnosis.
Specific nutrients for adrenal support
For a reliable analysis of your cortisol level and appropriate advice, it is advisable to always discuss the results of self-tests with a healthcare professional. The Department of Endocrinology at the LUMC, for example, deals with disorders of hormone-producing organs, including the adrenal glands that produce cortisol, and offers specialised diagnostics and treatments. disorders of the hormone-producing. This medical expertise is indispensable for an accurate interpretation of your hormonal status.
Which specific foods help to lower cortisol?
Diet plays an important role in regulating cortisol levels in the body. Although no single food is a cure-all in itself, a balanced diet can certainly contribute to maintaining a healthy hormonal balance. Think of foods rich in omega-3 fatty acids, such as oily fish and linseeds, which are known for their anti-inflammatory properties. Foods high in magnesium, such as green leafy vegetables, nuts and seeds, are also important, as magnesium contributes to relaxation and stress reduction. Regularly consuming probiotics, found in fermented products such as yoghurt and kefir, can have a positive influence on the gut-brain axis, which can indirectly affect the stress response and thereby cortisol levels.
Additional supplements and expert advice
Alongside a varied diet, additional supplements may be considered in some cases, although it is essential always to discuss this with a qualified healthcare professional. Examples include ashwagandha, an adaptogenic herb traditionally used for stress reduction, or rhodiola. Vitamin C, an antioxidant, can also provide support for adrenal function in certain situations. However, it is crucial to remember that supplements are a complement to a healthy lifestyle and not a replacement. For a personalised approach and to determine which dietary adjustments or supplements are appropriate, advice from a doctor or dietitian is invaluable. They can assess the individual situation and draw up a targeted plan, which contributes to a balanced cortisol level.
When is medical treatment for stress necessary?
When you continuously suffer from stress and this manifests as physical or mental symptoms that hinder your daily functioning, it is wise to seek medical help. A doctor can then assess whether the symptoms are related to your cortisol level or to other underlying conditions, and advise you on the most appropriate next steps. It is important to take these signals seriously and take timely action.
Diagnosing: from ‘exhaustion’ to imbalance
For an accurate assessment of your cortisol level and its potential impact on your well-being, a visit to a specialist is essential. Endocrinologists, who specialise in hormone-producing organs, can make a comprehensive diagnosis, including various diagnostic tests. The Endocrinology department of the LUMC, for example, deals with disorders of the hormone-producing organs, including the adrenal glands, where cortisol is produced Endocrinology Department. They often work with a multidisciplinary team, which may also involve specialist registrars in training (AIOS) in the consultations and treatments. This ensures a broad expertise and a careful approach to complex hormonal issues, which is essential for drawing up an effective treatment plan.
How do you build a daily routine for peace and energy?
A balanced daily routine is fundamental for managing your cortisol levels and promoting rest and energy. You can achieve this by keeping fixed times for getting up and going to bed, even at weekends. This consistency supports your biological clock, which in turn has a positive influence on the regulation of hormones, including cortisol. Throughout the day, it is advisable to alternate moments of activity with rest, while listening to your body's signals. A structured daily schedule helps to reduce unnecessary stress, as you have to make fewer ad-hoc decisions and creates more predictability in your daily routine.
Sensory and mental distraction during stress
Alongside a fixed structure, it is valuable to consciously build in sensory and mental distraction, especially when you experience tension. This can vary from listening to soothing music, taking a short walk in nature or applying breathing exercises. Such activities break the spiral of stress and offer your mind the chance to recover. By focusing on something other than the stressor, the production of cortisol decreases and space is created for relaxation. These conscious pauses are not a luxury, but a necessary part of a healthy daily routine that contributes to both mental and physical resilience.

Conclusion cortisol
Balancing your cortisol levels is crucial for your overall well-being, especially when dealing with hormonal fluctuations such as during the menopause. You have read how this important hormone affects your metabolism, immune system and stress response, and how an imbalance can lead to both physical and mental complaints. It is essential to understand that relaxation and a healthy lifestyle are fundamental to regulating cortisol. Although supplements can offer support, a holistic approach is always the most effective. Do you notice that stress and hormonal imbalance are affecting your daily life? Take control of your health. Have more questions contact op


